CCR5 Conformations Are Dynamic and Modulated by Localization, Trafficking and G Protein Association

Ayanna J. Flegler; Gianguido C. Cianci; Thomas J. Hope

doi:10.1371/journal.pone.0089056

Loading metrics

Open Access

Peer-reviewed

Research Article

CCR5 Conformations Are Dynamic and Modulated by Localization, Trafficking and G Protein Association

Ayanna J. Flegler,

Affiliation Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Gianguido C. Cianci,

Affiliation Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Thomas J. Hope

* E-mail: thope@northwestern.edu

Affiliation Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯

CCR5 Conformations Are Dynamic and Modulated by Localization, Trafficking and G Protein Association

Ayanna J. Flegler,
Gianguido C. Cianci,
Thomas J. Hope

Published: February 28, 2014
https://doi.org/10.1371/journal.pone.0089056

About the Authors

Ayanna J. Flegler

Affiliation Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Gianguido C. Cianci

Affiliation Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Thomas J. Hope

* E-mail: thope@northwestern.edu

Affiliation Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AJF GCC TJH. Performed the experiments: AJF. Analyzed the data: AJF GCC TJH. Contributed reagents/materials/analysis tools: TJH. Wrote the paper: AJF GCC TJH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Endocytosis
Is the Subject Area "Endocytosis" applicable to this article?

Thanks for your feedback.
CCR5 coreceptor
Is the Subject Area "CCR5 coreceptor" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Chemokines
Is the Subject Area "Chemokines" applicable to this article?

Thanks for your feedback.
Cell binding
Is the Subject Area "Cell binding" applicable to this article?

Thanks for your feedback.
Cell membranes
Is the Subject Area "Cell membranes" applicable to this article?

Thanks for your feedback.
Sucrose
Is the Subject Area "Sucrose" applicable to this article?

Thanks for your feedback.