Ablation of the Renal Stroma Defines Its Critical Role in Nephron Progenitor and Vasculature Patterning

Stephanie Hum; Christopher Rymer; Caitlin Schaefer; Daniel Bushnell; Sunder Sims-Lucas

doi:10.1371/journal.pone.0088400

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Research Article

Ablation of the Renal Stroma Defines Its Critical Role in Nephron Progenitor and Vasculature Patterning

Stephanie Hum,

Affiliations Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Christopher Rymer,

Affiliations Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Caitlin Schaefer,

Affiliations Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Daniel Bushnell,

Affiliations Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Sunder Sims-Lucas

* E-mail: simslucass@upmc.edu

Affiliations Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Ablation of the Renal Stroma Defines Its Critical Role in Nephron Progenitor and Vasculature Patterning

Stephanie Hum,
Christopher Rymer,
Caitlin Schaefer,
Daniel Bushnell,
Sunder Sims-Lucas

Published: February 5, 2014
https://doi.org/10.1371/journal.pone.0088400

About the Authors

Stephanie Hum

Affiliations Rangos Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Christopher Rymer

Caitlin Schaefer

Daniel Bushnell

Sunder Sims-Lucas

* E-mail: simslucass@upmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SH SSL. Performed the experiments: SH CR CS DB SSL. Analyzed the data: SH CR CS DB SSL. Wrote the paper: SH SSL.

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Kidneys
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Nephrons
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Apoptosis
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Glomeruli
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Kidney development
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Stromal cells
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