About the Authors

Steen Knudsen

steen@medical-prognosis.com

Affiliation Medical Prognosis Institute, Hørsholm, Denmark

Thomas Jensen

Affiliation Medical Prognosis Institute, Hørsholm, Denmark

Anker Hansen

Affiliation Medical Prognosis Institute, Hørsholm, Denmark

Wiktor Mazin

Affiliations Medical Prognosis Institute, Hørsholm, Denmark, Now at the Department of Clinical Epidemiology at Aarhus University Hospital, Aarhus C, Denmark

Justin Lindemann

Affiliation Astrazeneca UK Limited, Oncology iMED, Alderley Park, Cheshire, United Kingdom

Irene Kuter

Affiliation Massachusetts General Hospital, Massachusetts, Boston, United States of America

Naomi Laing

Affiliation Astrazeneca R&D Boston, Waltham, United States of America

Elizabeth Anderson

Affiliations Astrazeneca UK Limited, Oncology iMED, Alderley Park, Cheshire, United Kingdom, Now at Boehringer-Ingelheim RCV GmbH & Co KG, Vienna, Austria

Competing Interests

The authors have read the journal's policy and have the following conflicts. All authors declare past or present primary employment or ownership in a company (Astrazeneca or Medical Prognosis Institute) that has a potential to benefit from these results. Medical Prognosis Institute holds a patent application on the subject matter. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK JL EA. Performed the experiments: TJ AH IK. Analyzed the data: SK WM NL EA. Wrote the paper: SK NL EA.