About the Authors

Patrick J. Hensley

Affiliations Department of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Pathology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Andreas Desiniotis

Affiliation Department of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Chi Wang

Affiliation Department of Biostatistics, University of Kentucky College of Public Health, Lexington, Kentucky, United States of America

Arnold Stromberg

Affiliation Department of Statistics, University of Kentucky, Lexington, Kentucky, United States of America

Ching-Shih Chen

Affiliation Division of Medicinal Chemistry, Ohio State University College of Pharmacy, Columbus, Ohio, United States of America

Natasha Kyprianou

nkypr2@email.uky.edu

Affiliations Department of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Pathology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Toxicology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Molecular & Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

Competing Interests

Please note that the authors have declared the following COI: As the corresponding author, Natasha Kyprianou states that she serves as an Academic Editor of PLOS ONE Editorial Board, but confirms that this does not alter her adherence to all the PLOS ONE policies on sharing data and materials, as detailed in the guide for authors. Moreover, there is a patent relating to material pertinent in this article, i.e., the generation of the novel drug, DZ-50, by the authors Dr. Chen and Dr. Kyprianou. They declare this patent, named:”Novel Antitumor Agents and Methods of their Use in Targeting Prostate Cancer,” University of Kentucky/Ohio State University Joint Invention, U.S. Patent S.N. 12/323,073. (Ching-Shih Chen and Natasha Kyprianou, coinventors.) The authors confirm that the ownership/invention of this patent does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed in the guide to authors.

Author Contributions

Conceived and designed the experiments: NK PH. Performed the experiments: PH AD. Analyzed the data: NK CW AS PH. Contributed reagents/materials/analysis tools: CC CW AS. Wrote the paper: NK PH.