About the Authors
- Xiang Xu
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Contributed equally to this work with: Xiang Xu, Yuan Cai
Affiliation Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
- Yuan Cai
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Contributed equally to this work with: Xiang Xu, Yuan Cai
Affiliations Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, China
- Ying Wei
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Affiliation Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
- Fernando Donate
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Affiliation Agensys, St. Santa Monica, California, United States of America
- Jose Juarez
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Affiliation GNF, San Diego, California, United States of America
- Graham Parry
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Affiliation Attenuon, San Diego, California, United States of America
- Liqing Chen
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Affiliation Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, United States of America
- Edward J. Meehan
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Affiliation Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama, United States of America
- Richard W. Ahn
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Affiliation Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America
- Andrey Ugolkov
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Affiliation Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
- Oleksii Dubrovskyi
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Affiliation Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
- Thomas V. O'Halloran
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Affiliations Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America, Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America
- Mingdong Huang
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* E-mail: mhuang1@bidmc.harvard.edu (MH); a-mazar@northwestern.edu (APM)
Affiliation Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
- Andrew P. Mazar
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* E-mail: mhuang1@bidmc.harvard.edu (MH); a-mazar@northwestern.edu (APM)
Affiliations Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America
Competing Interests
The authors have the following interests. Fernando Donate, Jose Juarez, Graham Parry and Andrew P. Mazar were employed by Attenuon at the time of the study. Andrew Mazar and Thomas O'Halloran have equity interest and Andrew Mazar receives consulting fees from Tactic Pharma, a start-up company that now owns the rights to ATN-658. Andrew Mazar is an inventor on the issued patent for ATN-658. Several US patents have issued covering ATN-658 as well as the epitope. These patents are US# 8,101,726 “Ligands binding the complex of urokinase type plasminogen activator (uPA) and its receptor (uPAR) that inhibit downstream uPAR interactions: identification and use in diagnosis or therapy” (Parry and Mazar) and US# 8,105,602 “Urokinase type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof” (Parry and Mazar). There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: YW FD GP EJM TVO MH APM. Performed the experiments: XX YC YW JJ AU OD LC. Analyzed the data: TVO FD GP RWA AU MH EJM APM OD. Contributed reagents/materials/analysis tools: APM EJM MH. Wrote the paper: MH APM TVO YW FD GP.