About the Authors

Junji Yatsuda

Contributed equally to this work with: Junji Yatsuda, Atsushi Irie

Affiliations Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan, Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Atsushi Irie

Contributed equally to this work with: Junji Yatsuda, Atsushi Irie

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Kumiko Harada

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Yayoi Michibata

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Hirotake Tsukamoto

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Satoru Senju

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Yusuke Tomita

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Akira Yuno

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Masatoshi Hirayama

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Mohammad Abu Sayem

Affiliations Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

Naoki Takeda

Affiliation Division of Transgenic Technology, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan

Isao Shibuya

Affiliation Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

Shinji Sogo

Affiliation Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

Fumihiro Fujiki

Affiliation Department of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka, Japan

Haruo Sugiyama

Affiliation Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan

Masatoshi Eto

Affiliation Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Yasuharu Nishimura

mxnishim@gpo.kumamoto-u.ac.jp

Affiliation Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Competing Interests

IS and S. Sogo are current employees of Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd. and that YN is supported by a funding from Otsuka Pharmaceutical Co., Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JY AI YN. Performed the experiments: JY AI KH YM NT FF. Analyzed the data: JY AI HT S. Senju YN. Contributed reagents/materials/analysis tools: YT AY MH MAS IS S. Sogo HS ME. Wrote the manuscript: JY AI YN.