About the Authors

Rashid Mehmood

Contributed equally to this work with: Rashid Mehmood, Gabor Varga, Sonali Q. Mohanty

Affiliations Children's Health Research Institute, London, Ontario, Canada, Children's Health Research Institute, Department of Paediatrics, London, Ontario, Canada

Gabor Varga

Contributed equally to this work with: Rashid Mehmood, Gabor Varga, Sonali Q. Mohanty

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

Sonali Q. Mohanty

Contributed equally to this work with: Rashid Mehmood, Gabor Varga, Sonali Q. Mohanty

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

Scott W. Laing

Affiliations Children's Health Research Institute, London, Ontario, Canada, Children's Health Research Institute, Department of Paediatrics, London, Ontario, Canada, Children's Health Research Institute, Department of Physiology & Pharmacology, London, Ontario, Canada

Yuefeng Lu

Affiliation Biostatistics and Programming, Sanofi US, Framingham, Massachusetts, United States of America

Charis L. Johnson

Affiliations Children's Health Research Institute, London, Ontario, Canada, Children's Health Research Institute, Department of Paediatrics, London, Ontario, Canada

Alexei Kharitonenkov

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

Christopher L. Pin

cpin@uwo.ca

Affiliations Children's Health Research Institute, London, Ontario, Canada, Children's Health Research Institute, Department of Paediatrics, London, Ontario, Canada, Children's Health Research Institute, Department of Physiology & Pharmacology, London, Ontario, Canada, Oncology, the University of Western Ontario, London, Ontario, Canada

Competing Interests

Several of the authors are employed by Lilly Research Laboratories at Eli Lilly and Company (SM, GV and AK) or, Sanofi US, Framingham (YL). This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CP AK RM GV SM YL. Performed the experiments: RM SL CJ. Analyzed the data: RM GV SM YL SL CJ AK CP. Contributed reagents/materials/analysis tools: RM SL GV SM YL. Wrote the paper: RM GV SM AK CP. Obtained funding: AK CP.