Chronic Intermittent Hypoxia Exerts CNS Region-Specific Effects on Rat Microglial Inflammatory and TLR4 Gene Expression

Stephanie M. C. Smith; Scott A. Friedle; Jyoti J. Watters

doi:10.1371/journal.pone.0081584

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Open Access

Peer-reviewed

Research Article

Chronic Intermittent Hypoxia Exerts CNS Region-Specific Effects on Rat Microglial Inflammatory and TLR4 Gene Expression

Stephanie M. C. Smith,

Affiliation Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Scott A. Friedle,

Affiliation Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Jyoti J. Watters

* E-mail: jjwatters@wisc.edu

Affiliation Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America
⨯

Chronic Intermittent Hypoxia Exerts CNS Region-Specific Effects on Rat Microglial Inflammatory and TLR4 Gene Expression

Stephanie M. C. Smith,
Scott A. Friedle,
Jyoti J. Watters

Published: December 4, 2013
https://doi.org/10.1371/journal.pone.0081584

About the Authors

Stephanie M. C. Smith

Affiliation Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America

Scott A. Friedle

Affiliation Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America

Jyoti J. Watters

* E-mail: jjwatters@wisc.edu

Affiliation Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SMCS SAF JJW. Performed the experiments: SMCS SAF. Analyzed the data: SMCS SAF JJW. Wrote the paper: SMCS JJW.

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Microglial cells
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Inflammation
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Gene expression
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Central nervous system
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Brainstem
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Hypoxia
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Spinal cord
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Apoptosis
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