About the Authors

Kazuo Nakamoto

Affiliation Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan

Takashi Nishinaka

Affiliation Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan

Naoya Sato

Affiliation Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan

Mitsumasa Mankura

Affiliation Bizen Kasei Chemical Co. Ltd., Okayama, Japan

Yutaka Koyama

Affiliation Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan

Fumiyo Kasuya

Affiliation Biochemical Toxicology Laboratory, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan

Shogo Tokuyama

stoku@pharm.kobegakuin.ac.jp

Affiliation Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan

Competing Interests

Dr. Mitsumasa Mankura is an employee of Bizen Company. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: KN ST. Performed the experiments: KN TN NS ST. Analyzed the data: KN MM YK FK ST. Contributed reagents/materials/analysis tools: MM YK FK. Wrote the paper: KN ST.