Streptococcal SpeB Cleaved PAR-1 Suppresses ERK Phosphorylation and Blunts Thrombin-Induced Platelet Aggregation

Miriam Ender; Federica Andreoni; Annelies Sophie Zinkernagel; Reto Andreas Schuepbach

doi:10.1371/journal.pone.0081298

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Open Access

Peer-reviewed

Research Article

Streptococcal SpeB Cleaved PAR-1 Suppresses ERK Phosphorylation and Blunts Thrombin-Induced Platelet Aggregation

Miriam Ender,

Affiliation Division of Surgical Intensive Care Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland
⨯
Federica Andreoni,

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
⨯
Annelies Sophie Zinkernagel,

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
⨯
Reto Andreas Schuepbach

* E-mail: reto.schuepbach@usz.ch

Affiliation Division of Surgical Intensive Care Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland
⨯

Streptococcal SpeB Cleaved PAR-1 Suppresses ERK Phosphorylation and Blunts Thrombin-Induced Platelet Aggregation

Miriam Ender,
Federica Andreoni,
Annelies Sophie Zinkernagel,
Reto Andreas Schuepbach

Published: November 22, 2013
https://doi.org/10.1371/journal.pone.0081298

About the Authors

Miriam Ender

Affiliation Division of Surgical Intensive Care Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Federica Andreoni

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Annelies Sophie Zinkernagel

Affiliation Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Reto Andreas Schuepbach

* E-mail: reto.schuepbach@usz.ch

Affiliation Division of Surgical Intensive Care Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ME RAS ASZ. Performed the experiments: ME RAS FA. Analyzed the data: ME RAS FA ASZ. Contributed reagents/materials/analysis tools: ME RAS AZ FA. Wrote the manuscript: RAS ME.

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Thrombin
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Proteases
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Bacterial pathogens
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Streptococcus
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Enzyme-linked immunoassays
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Platelet aggregation
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Endothelial cells
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Virulence factors
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