About the Authors

Yuanjie Hu

Affiliation Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America

Ning Ru

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Huasheng Xiao

Affiliation National Engineering Center for Biochip at Shanghai, Shanghai, China

Abhishek Chaturbedi

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Neil T. Hoa

Affiliation Diagnostic & Molecular Health Care Group, Veterans Affairs Medical Center, Long Beach, California, United States of America

Xiao-Jun Tian

Affiliation Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, California, United States of America

Hang Zhang

Affiliation Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, California, United States of America

Chao Ke

Affiliations Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America, State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

Fengrong Yan

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Jodi Nelson

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Zhenzhi Li

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Robert Gramer

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Liping Yu

Affiliation Ziren Research LLC, Irvine, California, United States of America

Eric Siegel

Affiliation Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Xiaona Zhang

Affiliation National Engineering Center for Biochip at Shanghai, Shanghai, China

Zhenyu Jia

Affiliations Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang, China, Department of Statistics, University of Akron, Akron, Ohio, United States of America, Department of Family and Community Medicine, Northeast Ohio Medical University, Rootstown, Ohio, United States of America, Department of Pathology & Laboratory Medicine, University of California Irvine, Irvine, California, United States of America

Martin R. Jadus

Affiliations Diagnostic & Molecular Health Care Group, Veterans Affairs Medical Center, Long Beach, California, United States of America, Department of Pathology & Laboratory Medicine, University of California Irvine, Irvine, California, United States of America

Charles L. Limoli

Affiliation Department of Radiation Oncology, University of California Irvine, Irvine, California, United States of America

Mark E. Linskey

Affiliation Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Jianhua Xing

yihongz@uci.edu (Y-HZ); jxing@vt.edu (JX)

Affiliation Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, California, United States of America

Yi-Hong Zhou

yihongz@uci.edu (Y-HZ); jxing@vt.edu (JX)

Affiliations Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America, Department of Neurological Surgery, University of California Irvine, Irvine, California, United States of America

Competing Interests

Liping Yu is an employee of Ziren Research LLC, Irvine, CA, USA. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YZ. Performed the experiments: YH NR HX AC NH CK FY JN ZL LY XZ YZ RG. Analyzed the data: YH XT HZ ES ZJ MJ CL ML JX YZ. Contributed reagents/materials/analysis tools: HX LY MJ CL ML JX YZ. Wrote the paper: ML JX YZ.