In Vitro and In Vivo Characterization of Ultraviolet Light C-Irradiated Human Platelets in a 2 Event Mouse Model of Transfusion

Li Zhi; Xuan Chi; Jaroslav G. Vostal

doi:10.1371/journal.pone.0079869

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Open Access

Peer-reviewed

Research Article

In Vitro and In Vivo Characterization of Ultraviolet Light C-Irradiated Human Platelets in a 2 Event Mouse Model of Transfusion

Li Zhi,

Affiliation Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Xuan Chi,

Affiliation Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯
Jaroslav G. Vostal

* E-mail: jaroslav.vostal@fda.hhs.gov

Affiliation Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
⨯

In Vitro and In Vivo Characterization of Ultraviolet Light C-Irradiated Human Platelets in a 2 Event Mouse Model of Transfusion

Li Zhi,
Xuan Chi,
Jaroslav G. Vostal

Published: November 1, 2013
https://doi.org/10.1371/journal.pone.0079869

About the Authors

Li Zhi

Affiliation Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America

Xuan Chi

Affiliation Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America

Jaroslav G. Vostal

* E-mail: jaroslav.vostal@fda.hhs.gov

Affiliation Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LZ XC JGV. Performed the experiments: LZ XC. Analyzed the data: LZ XC JGV. Wrote the manuscript: LZ XC JGV.

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Platelets
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Ultraviolet C
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Platelet aggregation
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Platelet activation
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Mouse models
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Blood transfusion
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Ultraviolet B
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Light
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