About the Authors

Paul R. Hiebert

Affiliations UBC James Hogg Research Centre at the Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Wendy A. Boivin

Affiliations UBC James Hogg Research Centre at the Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Hongyan Zhao

Affiliation UBC James Hogg Research Centre at the Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, British Columbia, Canada

Bruce M. McManus

Affiliations UBC James Hogg Research Centre at the Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

David J. Granville

david.granville@hli.ubc.ca

Affiliations UBC James Hogg Research Centre at the Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Competing Interests

The authors have read the journal’s policy and have the following conflicts: DJG is a Founder and Scientific Officer to viDA Therapeutics, Inc., however, viDA was not involved in any aspect of this study. No commercial/therapeutic products from viDA were used in this study. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PRH WAB HZ BMM DJG. Performed the experiments: PRH WAB HZ. Analyzed the data: PRH WAB HZ. Contributed reagents/materials/analysis tools: BMM DJG. Wrote the manuscript: PRH WAB DJG.