About the Authors

Elana J. Fertig

ejfertig@jhmi.edu

Affiliation Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

Ana Markovic

Affiliation Department of Hematopoietic Malignancies, Hellen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

Ludmila V. Danilova

Affiliation Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

Daria A. Gaykalova

Affiliation Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

Leslie Cope

Affiliation Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

Christine H. Chung

Affiliation Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

Michael F. Ochs

Affiliations Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Health Science Informatics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Joseph A. Califano

Affiliations Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America

Competing Interests

Dr. Califano is the Director of Research of the Milton J. Dance Head and Neck Endowment. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies. In addition, the authors note that he is a PLOS ONE editorial board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EJF AM CHC JA MFO. Performed the experiments: AM DAG. Analyzed the data: EJF LVD MFO. Contributed reagents/materials/analysis tools: EJF AM DAG LVD LC CHC MFO JAC. Wrote the paper: EJF AM DAG LVD LC CHC MFO JAC. Developed the integrated meta-pathway analysis algorithm: EJF. Theoretical contributions to meta-pathway analysis: LVD LC MFO.