About the Authors

Henriette Frikke-Schmidt

Affiliations Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, United States of America, Department of Insulin Biology, Novo Nordisk A/S, Maaloev, Denmark

Thomas Åskov Pedersen

Affiliation Department of Insulin Biology, Novo Nordisk A/S, Maaloev, Denmark

Christian Fledelius

Affiliation Department of Insulin Pharmacology, Novo Nordisk A/S, Maaloev, Denmark

Grith Skytte Olsen

Affiliation Department of Insulin Biology, Novo Nordisk A/S, Maaloev, Denmark

Marc Hellerstein

march@berkeley.edu

Affiliations Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, United States of America, KineMed, Inc., Emeryville, California, United States of America

Competing Interests

The authors declare that the study was funded by Novo Nordisk A/S through which the authors HF-S, TÅP, GSO, and CF all are employees and stakeholders. The insulin used for the experiments has been provided by Novo Nordisk A/S. All Intellectual Property Rights of the current study are owned by University of California Berkeley and there has been no compromise of the objectivity or validity of the data in the manuscript. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HFS TÅP GSO CF MH. Performed the experiments: HFS. Analyzed the data: HFS. Contributed reagents/materials/analysis tools: MH. Wrote the manuscript: HFS MH. Reviewed the manuscript prior to submission: HFS TÅP GSO CF MH.