Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

Lijuan Kang; Maria K. Janowska; Gina M. Moriarty; Jean Baum

doi:10.1371/journal.pone.0075018

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Open Access

Peer-reviewed

Research Article

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

Lijuan Kang,

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Maria K. Janowska,

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Gina M. Moriarty,

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Jean Baum

* E-mail: jean.baum@rutgers.edu

Affiliations Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America, BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯

Mechanistic Insight into the Relationship between N-Terminal Acetylation of α-Synuclein and Fibril Formation Rates by NMR and Fluorescence

Lijuan Kang,
Maria K. Janowska,
Gina M. Moriarty,
Jean Baum

Published: September 18, 2013
https://doi.org/10.1371/journal.pone.0075018

About the Authors

Lijuan Kang

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

Maria K. Janowska

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

Gina M. Moriarty

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

Jean Baum

* E-mail: jean.baum@rutgers.edu

Affiliations Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America, BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JB LK. Performed the experiments: LK. Analyzed the data: LK MKJ GMM. Contributed reagents/materials/analysis tools: JB. Wrote the manuscript: LK MKJ GMM JB.

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Monomers
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Acetylation
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Amyloid proteins
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Parkinson disease
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Substitution mutation
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Protein structure
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Chemical deposition
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Kinetics
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