About the Authors

Antonella Del-Corso, Francesco Balestri, Elisa Di Bugno, Roberta Moschini, Mario Cappiello, Umberto Mura
Biochemistry Unit at the Department of Biology, University of Pisa, Pisa, Italy

Stefania Sartini, Concettina La-Motta, Federico Da-Settimo
Department of Pharmaceutical Sciences, University of Pisa, Pisa, Italy

Corresponding Author

umura@biologia.unipi.it

Competing Interests

This work was supported in part by Pisa University and in part by Opocrin, S.p.A. (Modena, Italy). The commercial funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The presence of the commercial funder does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: UM MC ADC. Performed the experiments: FB MC ADC EDB RM UM. Analyzed the data: FB MC FDS ADC CLM RM UM. Wrote the manuscript: MC FDS ADC CLM RM UM. Designed and synthesized the inhibitors: FDS CLM SS.