About the Authors
- Maki Komiyama
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Affiliations Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan, Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan
- Hiromichi Wada
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Affiliation Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
- Shuichi Ura
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Affiliation Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
- Hajime Yamakage
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Affiliation Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
- Noriko Satoh-Asahara
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Affiliation Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
- Akira Shimatsu
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Affiliation Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
- Hiroshi Koyama
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Affiliation Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
- Koichi Kono
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Affiliation Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan
- Yuko Takahashi
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Affiliation Health Care Center, Nara Women’s University, Nara, Japan
- Koji Hasegawa
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* E-mail: koj@kuhp.kyoto-u.ac.jp
Affiliation Division of Translational Research, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
Competing Interests
One drug studied in the work, varenicline, is manufactured by Pfizer. While funding was received from Pfizer Health Research Foundation, the authors confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: AS HK KK YT KH. Analyzed the data: HW HY NSA. Contributed reagents/materials/analysis tools: SU. Wrote the paper: MK.