About the Authors

Rolf Spirig

Contributed equally to this work with: Rolf Spirig, Alexander Schaub

Affiliations Laboratory of Cardiovascular Research, Department of Clinical Research, University of Bern, Bern, Switzerland, CSL Behring AG, Bern, Switzerland

Alexander Schaub

Contributed equally to this work with: Rolf Spirig, Alexander Schaub

Affiliation CSL Behring AG, Bern, Switzerland

Alain Kropf

Affiliation CSL Behring AG, Bern, Switzerland

Sylvia Miescher

Affiliation CSL Behring AG, Bern, Switzerland

Martin O. Spycher

Affiliation CSL Behring AG, Bern, Switzerland

Robert Rieben

robert.rieben@dkf.unibe.ch

Affiliation Laboratory of Cardiovascular Research, Department of Clinical Research, University of Bern, Bern, Switzerland

Competing Interests

Although Rolf Spirig, Alexander Schaub, Alain Kropf, Sylvia Miescher and Martin Spycher are employees of CSL Behring (Switzerland), this does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RS AS. Performed the experiments: RS AS AK. Analyzed the data: RS AS AK SM MS RR. Contributed reagents/materials/analysis tools: SM MS RR. Wrote the paper: RS AS RR. Obtained funding: RR. Critical revision of the manuscript: SM MS.