About the Authors

Taiko Nishino

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan, Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa, Japan

Ayako Yachie-Kinoshita

ayako.yachie.kinoshita@utoronto.ca

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Onatrio, Canada, Department of Biochemistry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

Akiyoshi Hirayama

Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan

Tomoyoshi Soga

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan, Faculty of Environment and Information Studies, Keio University, Fujisawa, Kanagawa, Japan

Makoto Suematsu

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan, Department of Biochemistry, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

Masaru Tomita

Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan, Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa, Japan, Faculty of Environment and Information Studies, Keio University, Fujisawa, Kanagawa, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TN AYK. Performed the experiments: TN AYK. Analyzed the data: TN AYK. Contributed reagents/materials/analysis tools: TN AH. Wrote the paper: TN AYK. Supervised overall for this research: MT. Provided environment and supervised for the metabolome analysis: TS. Provided environment for blood sampling and supervised for this research: MS.