About the Authors

Michael P. Gardner

Affiliation School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, United Kingdom

Carmen Martin-Ruiz

Affiliation Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

Rachel Cooper

Affiliation MRC Unit for Lifelong Health and Ageing, University College London, London, United Kingdom

Rebecca Hardy

Affiliation MRC Unit for Lifelong Health and Ageing, University College London, London, United Kingdom

Avan Aihie Sayer

Affiliation Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom

Cyrus Cooper

Affiliation Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom

Ian J. Deary

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

John Gallacher

Affiliation Department of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom

Sarah E. Harris

Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Medical Genetics Section, University of Edinburgh, Edinburgh, United Kingdom

Paul G. Shiels

Affiliation Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

John M. Starr

Affiliation Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom

Diana Kuh

Affiliation MRC Unit for Lifelong Health and Ageing, University College London, London, United Kingdom

Thomas von Zglinicki

Affiliation Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

Yoav Ben-Shlomo

Y.Ben-Shlomo@bristol.ac.uk

Affiliation School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, United Kingdom

the Halcyon study team

Membership of the Halcyon Study Team is provided in the Acknowledgments.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MG DK TVZ YBS. Performed the experiments: C-MR TVZ. Analyzed the data: MG RC. Contributed reagents/materials/analysis tools: C-MR TVZ. Wrote the paper: MG. Harmonised the physical capability measures and managed the Halcyon database: RC RH. Provided scientific input: PS. Designed and collected data for the Hertfordshire Ageing Study: AAS CC. Designed and collected data for LBC1921: IJD JMS SEH. Designed and collected data for CaPS: JG. Designed and collected data for NSHD: DK. Contributed to and approved the final manuscript: MG C-MR RC RH AAS CC IJD JG SEH PGS JMS DK TVZ YBS.