About the Authors
- Amrit Singh
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Affiliations James Hogg Research Centre, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, Institute for HEART+LUNG Health, Vancouver, British Columbia, Canada, NCE CECR PROOF Centre of Excellence, Vancouver, British Columbia, Canada
- Masatsugu Yamamoto
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Affiliations James Hogg Research Centre, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, Institute for HEART+LUNG Health, Vancouver, British Columbia, Canada, Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
- Sarah H. Y. Kam
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Affiliations James Hogg Research Centre, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, Institute for HEART+LUNG Health, Vancouver, British Columbia, Canada
- Jian Ruan
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Affiliations James Hogg Research Centre, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, Institute for HEART+LUNG Health, Vancouver, British Columbia, Canada
- Gail M. Gauvreau
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Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada
- Paul M. O'Byrne
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Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada
- J. Mark FitzGerald
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Affiliations Institute for HEART+LUNG Health, Vancouver, British Columbia, Canada, Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada, Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada
- Robert Schellenberg
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Affiliations James Hogg Research Centre, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
- Louis-Philippe Boulet
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Affiliation Centre de Pneumologie de L’Hopital, Université Laval, Sainte-Foy, Quebec, Canada
- Gabriella Wojewodka
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Affiliation Department of Human Genetics, McGill University, Montreal, Quebec, Canada
- Cynthia Kanagaratham
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Affiliation Department of Human Genetics, McGill University, Montreal, Quebec, Canada
- Juan B. De Sanctis
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Affiliations Department of Human Genetics, McGill University, Montreal, Quebec, Canada, Central University of Venezuela, Institute of Immunology, Caracas, Venezuela
- Danuta Radzioch
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Affiliation Department of Human Genetics, McGill University, Montreal, Quebec, Canada
- Scott J. Tebbutt
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* E-mail: Scott.Tebbutt@hli.ubc.ca
Affiliations James Hogg Research Centre, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada, Institute for HEART+LUNG Health, Vancouver, British Columbia, Canada, NCE CECR PROOF Centre of Excellence, Vancouver, British Columbia, Canada, Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Competing Interests
The authors have the following interests. This study was funded by AllerGen NCE Inc. Metabolon Incorporated (Durham, North Carolina, United States) performed the metabolite profiling and data processing for this study. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: GMG PMO JMF L-PB DR SJT. Analyzed the data: AS SHYK GMG GW CK DR SJT. Wrote the paper: AS MY SHYK JR GMG PMO JMF RS L-PB GW CK JBD DR SJT.