About the Authors

Sylwia M. Figarska

Affiliations University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands

Judith M. Vonk

Affiliations University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands

Cleo C. van Diemen

Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

Dirkje S. Postma

Affiliations University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands

H. Marike Boezen

h.m.boezen@umcg.nl

Affiliations University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands

Competing Interests

DS Postma has received funding from for research from AstraZeneca, GSK, Nycomed and has been consultant to AstraZeneca, Boehringer Ingelheim, Chiesi, GSK, Nycomed, TEVA. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. SMF JMC CCvD and HMB have no competing interests.

Author Contributions

Conceived and designed the experiments: SMF JMV HMB. Performed the experiments: CCvD. Analyzed the data: SMF JMV HMB. PIs of the mortality study funded by Stichting Astma Bestrijding: HMB JMV. PIs of the genetic study funded by the Netherlands Asthma Foundation: HMB DSP. Wrote the first draft of the article: SMF. Contributed to the writing of the paper: SMF JMV CCvD DSP HMB.