About the Authors

Jiang Gui

Affiliations Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, New Hampshire, United States of America, Section of Biostatistics and Epidemiology, Departments of Community and Family Medicine, Geisel School of Medicine, Lebanon, New Hampshire, United States of America

Jason H. Moore

jason.h.moore@dartmouth.edu

Affiliations Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, New Hampshire, United States of America, Section of Biostatistics and Epidemiology, Departments of Community and Family Medicine, Geisel School of Medicine, Lebanon, New Hampshire, United States of America, Department of Genetics, Geisel School of Medicine, Lebanon, New Hampshire, United States of America

Scott M. Williams

Affiliations Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, New Hampshire, United States of America, Department of Genetics, Geisel School of Medicine, Lebanon, New Hampshire, United States of America

Peter Andrews

Affiliation Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, New Hampshire, United States of America

Hans L. Hillege

Affiliation Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands

Pim van der Harst

Affiliation Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands

Gerjan Navis

Affiliation Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands

Wiek H. Van Gilst

Affiliation Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands

Folkert W. Asselbergs

Affiliation Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

Diane Gilbert-Diamond

Affiliations Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Lebanon, New Hampshire, United States of America, Section of Biostatistics and Epidemiology, Departments of Community and Family Medicine, Geisel School of Medicine, Lebanon, New Hampshire, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHM. Wrote the paper: JG. Analyzed the simulated data and real data: JG. Edited the discussion section of the manuscript: JHM FWA. Contributed materials and edited the simulation section: SMW. Developed a Java version of the proposed method, analyzed the simulation data: PA. Contributed materials in real data: HLH PvdH GN WHVG FWA. Edited the Introduction, simulation, and results sections of the manuscript: DG-D.