About the Authors

Steven Haney

haney_steven_a@lilly.com

Current address: Department of Quantitative Biology, Eli Lilly Pharmaceuticals, Indianapolis, Indiana, United States of America

Affiliation Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, United States of America

Juan Zhao

Affiliation Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, United States of America

Shiwani Tiwari

Affiliation Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, United States of America

Kurt Eng

Current address: Drug Metabolism and Pharmacokinetics, Millennium Pharmaceuticals, Cambridge, Massachusetts, United States of America

Affiliation Oligonucleotide Therapeutics Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, United States of America

Lin T. Guey

Current address: Department of Biology, Shire Therapeutics HGT, Lexington, Massachusetts, United States of America

Affiliation Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, United States of America

Eric Tien

Current address: Discovery Toxicology, Amgen Inc, Thousand Oaks, California, United States of America

Affiliation Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have the following interests. All authors were employed by Pfizer Pharmaceuticals at the time of this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SH KE LT ET. Performed the experiments: SH ST JZ ET. Analyzed the data: SH LG ET. Contributed reagents/materials/analysis tools: SH ST JZ KE LT ET. Wrote the paper: SH LG ET.