About the Authors

Nirianne Marie Q. Palacpac

Contributed equally to this work with: Nirianne Marie Q. Palacpac, Edward Ntege

Affiliations Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan, The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan

Edward Ntege

Contributed equally to this work with: Nirianne Marie Q. Palacpac, Edward Ntege

Affiliation Med Biotech Laboratories, Kampala, Uganda

Adoke Yeka

Affiliations Med Biotech Laboratories, Kampala, Uganda, Makerere University School of Public Health, Kampala, Uganda

Betty Balikagala

Affiliation Med Biotech Laboratories, Kampala, Uganda

Nahoko Suzuki

Affiliation The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan

Hiroki Shirai

Affiliation The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan

Masanori Yagi

Affiliation Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Kazuya Ito

Affiliations Department of Public Health, Faculty of Medicine, Osaka City University, Osaka, Japan, Sumida Hospital, Medical Co. Living Together Association (LTA) Clinical Pharmacology Center, Tokyo, Japan

Wakaba Fukushima

Affiliation Department of Public Health, Faculty of Medicine, Osaka City University, Osaka, Japan

Yoshio Hirota

Affiliation Department of Public Health, Faculty of Medicine, Osaka City University, Osaka, Japan

Christopher Nsereko

Current address: International Hospital Kampala, Kampala, Uganda

Affiliation Lira Medical Centre, Lira, Uganda

Takuya Okada

Affiliation The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan

Bernard N. Kanoi

Affiliation Med Biotech Laboratories, Kampala, Uganda

Kohhei Tetsutani

Affiliations The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan, Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Ibaraki City, Osaka, Japan

Nobuko Arisue

Affiliation Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Sawako Itagaki

Affiliation Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Takahiro Tougan

Affiliation Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Ken J. Ishii

Affiliations Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Ibaraki City, Osaka, Japan, Laboratory of Vaccine Science, Immunology Frontier Research Center, World Premier Institute for Immunology, Osaka University, Suita, Osaka, Japan

Shigeharu Ueda

Affiliation The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan

Thomas G. Egwang

Affiliation Med Biotech Laboratories, Kampala, Uganda

Toshihiro Horii

horii@biken.osaka-u.ac.jp

Affiliation Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Competing Interests

TH and BIKEN hold patent for BK-SE36. BIKEN provided funding for this study. SU is a member of the Board of Directors of BIKEN. HS (Department Manager, Production Technology Department), NS and TO are/were employees of BIKEN. KT was a former consigned staff of BIKEN and NMQP was employed as a researcher of BIKEN during the trial conduct. TGE (Principal Investigator), AY (Co-Principal Investigator), Clinical investigators: EN, CN and BB; and BNK (Laboratory Technical Supervisor) received honoraria from BIKEN to undertake the clinical trial and follow-up study. TH and KJI are medical advisers of the clinical trial but have not received any honoraria or personal payment from BIKEN. These do not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials. None of the other authors have competing interests.

Author Contributions

Conceived and designed the experiments: TH KJI NMQP NS TO KT HS. Performed the experiments: TGE AY EN BB CN HS NS NMQP TO MY. Analyzed the data: TH NMQP NS KI WF YH. Contributed reagents/materials/analysis tools: SU HS KT NMQP NS TO MY NA SI TT KI. Wrote the paper: TH NMQP KJI AY TGE KI TT EN. Regulatory and ethical submissions: EN TGE NS SU HS TO NMQP.