Conformational B-Cell Epitope Prediction on Antigen Protein Structures: A Review of Current Algorithms and Comparison with Common Binding Site Prediction Methods

Bo Yao; Dandan Zheng; Shide Liang; Chi Zhang

doi:10.1371/journal.pone.0062249

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Open Access

Peer-reviewed

Research Article

Conformational B-Cell Epitope Prediction on Antigen Protein Structures: A Review of Current Algorithms and Comparison with Common Binding Site Prediction Methods

Bo Yao,

Affiliation School of Biological Sciences, Center for Plant Science and Innovation, University of Nebraska, Lincoln, Nebraska, United States of America
⨯
Dandan Zheng,

Affiliation Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Shide Liang ,

* E-mail: czhang5@unl.edu (CZ); shideliang@hotmail.com (SL)

Affiliation Systems Immunology Lab, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
⨯
Chi Zhang

* E-mail: czhang5@unl.edu (CZ); shideliang@hotmail.com (SL)

Affiliation School of Biological Sciences, Center for Plant Science and Innovation, University of Nebraska, Lincoln, Nebraska, United States of America
⨯

Conformational B-Cell Epitope Prediction on Antigen Protein Structures: A Review of Current Algorithms and Comparison with Common Binding Site Prediction Methods

Bo Yao,
Dandan Zheng,
Shide Liang,
Chi Zhang

Published: April 19, 2013
https://doi.org/10.1371/journal.pone.0062249

About the Authors

Bo Yao

Affiliation School of Biological Sciences, Center for Plant Science and Innovation, University of Nebraska, Lincoln, Nebraska, United States of America

Dandan Zheng

Affiliation Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Shide Liang

* E-mail: czhang5@unl.edu (CZ); shideliang@hotmail.com (SL)

Affiliation Systems Immunology Lab, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Chi Zhang

* E-mail: czhang5@unl.edu (CZ); shideliang@hotmail.com (SL)

Affiliation School of Biological Sciences, Center for Plant Science and Innovation, University of Nebraska, Lincoln, Nebraska, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BY CZ SL. Performed the experiments: BY DZ SL CZ. Analyzed the data: BY DZ. Wrote the paper: DZ SL CZ.

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Forecasting
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B cells
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Protein structure prediction
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Antigenic variation
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Crystal structure
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Protein structure
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Antigens
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Algorithms
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