About the Authors

Junpei Suzuki

Affiliations Department of Pharmacogenomics, Graduate School of Pharmaceutical Science, Chiba University, Chuo-ku, Chiba, Japan, Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan

Makoto Kuwahara

Affiliation Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan

Soichi Tofukuji

Affiliations Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan, Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan

Masashi Imamura

Affiliation Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Kusatsu, Shiga, Japan

Fuminori Kato

Affiliation Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Kusatsu, Shiga, Japan

Toshinori Nakayama

Affiliations Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan, CREST, Japan Science and Technology Agency, Chuo-ku, Chiba, Japan

Osamu Ohara

Affiliation Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan

Masakatsu Yamashita

yamamasa@m.ehime-u.ac.jp

Affiliations Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan, Department of Immunology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan, PRESTO, Japan Science and Technology Agency, Toon, Ehime, Japan

Competing Interests

The authors have the following interests. Authors MI and FK are employees of Ishihara Sangyo Kaisha, Ltd., the company that provided the SH-2251 (United States Patent No.: US 7632865 B2) for this study. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JS MY. Performed the experiments: JS MK ST TN OO MY. Analyzed the data: JS MK. Contributed reagents/materials/analysis tools: MI FK. Wrote the paper: JS MY.