About the Authors

Michael Centola

Contributed equally to this work with: Michael Centola, Guy Cavet

Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Guy Cavet

Contributed equally to this work with: Michael Centola, Guy Cavet

glcavet@gmail.com

Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America

Yijing Shen

Affiliation Department of Biostatistics and Bioinformatics, Crescendo Bioscience, Inc., South San Francisco, California, United States of America

Saroja Ramanujan

Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America

Nicholas Knowlton

Affiliation Biomarker & Proteomic Core Facility, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Kathryn A. Swan

Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America

Mary Turner

Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Chris Sutton

Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Dustin R. Smith

Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

Douglas J. Haney

Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America

David Chernoff

Affiliation Department of Medicine, Crescendo Bioscience, Inc., South San Francisco, California, United States of America

Lyndal K. Hesterberg

Affiliation Department of Development, Crescendo Bioscience, Inc., South San Francisco, California, United States of America

John P. Carulli

Affiliation Genetics and Genomics Group, Biogen Idec, Cambridge, Massachusetts, United States of America

Peter C. Taylor

Affiliation Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

Nancy A. Shadick

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

Michael E. Weinblatt

Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

Jeffrey R. Curtis

Affiliation Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Competing Interests

The authors have the following interests. This work was partly supported by Crescendo Bioscience and Biogen Idec. GC, YS, SR, KS, DS, DH, LH: employees of Crescendo Bioscience; MC, NK, CS, DC, PT, MW, JC: consultants to Crescendo Bioscience; GC, YS, SR, KS, DS, DH, LH, MC, CS, DC: stock options in Crescendo Bioscience. GC, MC, NK, YS: inventors on US patent application #20110137851 (“Biomarkers and Methods for Measuring and Monitoring Inflammatory Disease Activity”) based on this work. JPC is employed by Biogen Idec. This paper describes the development of a diagnostics technology currently marketed by Crescendo Bioscience. There are no further patents, products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MC GC MT CS DS DC LH J. Carulli PT NS MW J. Curtis. Performed the experiments: MC MT CS DS PT J. Curtis MW KS. Analyzed the data: MC GC YS SR NK DH PT KS. Wrote the paper: MC GC YS SR NK MT CS DS DH DC LH J. Carulli PT NS MW J. Curtis KS.