About the Authors
- Michael Centola
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Contributed equally to this work with: Michael Centola, Guy Cavet
Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
- Guy Cavet
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Contributed equally to this work with: Michael Centola, Guy Cavet
* E-mail: glcavet@gmail.com
Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America
- Yijing Shen
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Affiliation Department of Biostatistics and Bioinformatics, Crescendo Bioscience, Inc., South San Francisco, California, United States of America
- Saroja Ramanujan
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Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America
- Nicholas Knowlton
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Affiliation Biomarker & Proteomic Core Facility, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
- Kathryn A. Swan
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Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America
- Mary Turner
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Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
- Chris Sutton
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Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
- Dustin R. Smith
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Affiliation Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
- Douglas J. Haney
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Affiliation Department of Informatics, Crescendo Bioscience Inc., South San Francisco, California, United States of America
- David Chernoff
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Affiliation Department of Medicine, Crescendo Bioscience, Inc., South San Francisco, California, United States of America
- Lyndal K. Hesterberg
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Affiliation Department of Development, Crescendo Bioscience, Inc., South San Francisco, California, United States of America
- John P. Carulli
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Affiliation Genetics and Genomics Group, Biogen Idec, Cambridge, Massachusetts, United States of America
- Peter C. Taylor
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Affiliation Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
- Nancy A. Shadick
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Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
- Michael E. Weinblatt
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Affiliation Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
- Jeffrey R. Curtis
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Affiliation Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Competing Interests
The authors have the following interests. This work was partly supported by Crescendo Bioscience and Biogen Idec. GC, YS, SR, KS, DS, DH, LH: employees of Crescendo Bioscience; MC, NK, CS, DC, PT, MW, JC: consultants to Crescendo Bioscience; GC, YS, SR, KS, DS, DH, LH, MC, CS, DC: stock options in Crescendo Bioscience. GC, MC, NK, YS: inventors on US patent application #20110137851 (“Biomarkers and Methods for Measuring and Monitoring Inflammatory Disease Activity”) based on this work. JPC is employed by Biogen Idec. This paper describes the development of a diagnostics technology currently marketed by Crescendo Bioscience. There are no further patents, products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: MC GC MT CS DS DC LH J. Carulli PT NS MW J. Curtis. Performed the experiments: MC MT CS DS PT J. Curtis MW KS. Analyzed the data: MC GC YS SR NK DH PT KS. Wrote the paper: MC GC YS SR NK MT CS DS DH DC LH J. Carulli PT NS MW J. Curtis KS.