About the Authors

Ci Song

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Nancy L. Pedersen

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Chandra A. Reynolds

Affiliation University of California Riverside, Riverside, California, United States of America

Maria Sabater-Lleal

Affiliation Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

Stavroula Kanoni

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Christina Willenborg

Affiliations Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Lübeck, Germany

the CARDIoGRAMplusC4D Consortium

Membership of the CARDIoGRAMplusC4D Consortium is provided in File S1.

Ann-Christine Syvänen

Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Hugh Watkins

Affiliations Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom

Anders Hamsten

Affiliations Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden

Jonathan A. Prince

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Erik Ingelsson

erik.ingelsson@medsci.uu.se

Affiliations Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Competing Interests

Several authors of the original CARDIoGRAMplusC4D study that provided in silico data for one SNP of the present study are employees of deCODE genetics. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CS NLP CAR JAP EI. Performed the experiments: CS NLP CAR MS-L SK CW ACS HW AH JAP EI. Analyzed the data: CS MS-L SK CW EI. Contributed reagents/materials/analysis tools: NLP CAR ACS HW AH JAP EI. Wrote the paper: CS EI.