Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism

Kelsey Caetano-Anollés; Gustavo Caetano-Anollés

doi:10.1371/journal.pone.0059300

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Open Access

Peer-reviewed

Research Article

Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism

Kelsey Caetano-Anollés,

Affiliations Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Chicago School of Professional Psychology, Chicago, Illinois, United States of America
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Gustavo Caetano-Anollés

* E-mail: gca@uiuc.edu

Affiliation Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
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Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism

Kelsey Caetano-Anollés,
Gustavo Caetano-Anollés

Published: March 13, 2013
https://doi.org/10.1371/journal.pone.0059300

About the Authors

Kelsey Caetano-Anollés

Affiliations Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Chicago School of Professional Psychology, Chicago, Illinois, United States of America

Gustavo Caetano-Anollés

* E-mail: gca@uiuc.edu

Affiliation Evolutionary Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KCA GCA. Performed the experiments: KCA. Analyzed the data: KCA GCA. Wrote the paper: KCA GCA.

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Enzyme metabolism
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Enzymes
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Protein domains
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Purine metabolism
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Enzyme structure
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Protein metabolism
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Purines
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Enzyme chemistry
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