TGF-β Superfamily Gene Expression and Induction of the Runx1 Transcription Factor in Adult Neurogenic Regions after Brain Injury

Trevor T. Logan; Sonia Villapol; Aviva J. Symes

doi:10.1371/journal.pone.0059250

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Open Access

Peer-reviewed

Research Article

TGF-β Superfamily Gene Expression and Induction of the Runx1 Transcription Factor in Adult Neurogenic Regions after Brain Injury

Trevor T. Logan,

Affiliations Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Sonia Villapol,

Affiliations Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Aviva J. Symes

* E-mail: aviva.symes@usuhs.edu

Affiliations Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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TGF-β Superfamily Gene Expression and Induction of the Runx1 Transcription Factor in Adult Neurogenic Regions after Brain Injury

Trevor T. Logan,
Sonia Villapol,
Aviva J. Symes

Published: March 21, 2013
https://doi.org/10.1371/journal.pone.0059250

About the Authors

Trevor T. Logan

Affiliations Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Sonia Villapol

Aviva J. Symes

* E-mail: aviva.symes@usuhs.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TTL SV AJS. Performed the experiments: TTL SV. Analyzed the data: TTL SV AJS. Contributed reagents/materials/analysis tools: AJS. Wrote the paper: TTL SV AJS.

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Microglial cells
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Adult neurogenesis
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Traumatic brain injury
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Stem cells
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BMP signaling
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Gene expression
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Neurons
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Astrocytes
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