About the Authors

Alexei Kharitonenkov

a.kharch@lilly.com

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

John M. Beals

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Radmila Micanovic

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Beth A. Strifler

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Radhakrishnan Rathnachalam

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Victor J. Wroblewski

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Shun Li

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Anja Koester

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Amy M. Ford

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Tamer Coskun

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

James D. Dunbar

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Christine C. Cheng

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Christopher C. Frye

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Thomas F. Bumol

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

David E. Moller

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, United States of America

Competing Interests

All authors of the manuscript were employees of Eli Lilly & Company at the time the research supporting this manuscript was conducted. There are no ongoing clinical development studies with LY2405319. LY2405319 holds the following patents relating to material pertinent to this research (Christopher Carl Frye, Lihua Huang, Radmila Micanovic); WO 2006/028595 (US 7,582,607), filed July 26, 2005 (Eli Lilly and Company). There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK JMB RM RR VJW CCF TFB DEM. Performed the experiments: BAS SL AK AMF TC JDD CCC. Analyzed the data: AK JMB RM AK RR VJW JDD CCF. Wrote the paper: AK JMB CCF JDD DEM.