About the Authors
- Julian I. Borissoff
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* E-mail: j.ilcheff@maastrichtuniversity.nl
Affiliations Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
- Jeroen J. T. Otten
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Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
- Sylvia Heeneman
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Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
- Peter Leenders
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Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
- René van Oerle
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Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
- Oliver Soehnlein
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Current address: Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University (LMU), Munich, Germany
Affiliation Institute for Cardiovascular Molecular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany
- Sarah T. B. G. Loubele
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Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
- Karly Hamulyák
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Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
- Tilman M. Hackeng
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Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
- Mat J. A. P. Daemen
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Current address: Department of Pathology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
- Jay L. Degen
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Affiliation Developmental Biology, Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
- Hartmut Weiler
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Affiliation Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, United States of America
- Charles T. Esmon
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Affiliation Oklahoma Medical Research Foundation and Howard Hughes Medical Institute, Oklahoma City, Oklahoma, United States of America
- Joanne van Ryn
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Affiliation Department of CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
- Erik A. L. Biessen
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Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
- Henri M. H. Spronk
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Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
- Hugo ten Cate
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Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
Competing Interests
The authors have the following interests. Boehringer Ingelheim GmbH provided Dabigatran etexilate-supplemented and placebo diets for this study and is the employer of Joanne van Ryn. Dr. ten Cate has received speaker fees from Bayer, Boehringer Ingelheim, GlaxoSmithKline and Leo Pharma. There are no further patents, products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JIB EALB SH MJAPD HMS HtC. Performed the experiments: JIB JJTO PL RvO OS STBGL. Analyzed the data: JIB JJTO PL RvO OS STBGL HMS HtC. Contributed reagents/materials/analysis tools: KH TMH MJAPD JLD HW CTE JvR. Wrote the paper: JIB HMS HtC.