About the Authors

Julian I. Borissoff

j.ilcheff@maastrichtuniversity.nl

Affiliations Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

Jeroen J. T. Otten

Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

Sylvia Heeneman

Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

Peter Leenders

Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

René van Oerle

Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

Oliver Soehnlein

Current address: Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University (LMU), Munich, Germany

Affiliation Institute for Cardiovascular Molecular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany

Sarah T. B. G. Loubele

Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

Karly Hamulyák

Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

Tilman M. Hackeng

Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

Mat J. A. P. Daemen

Current address: Department of Pathology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands

Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

Jay L. Degen

Affiliation Developmental Biology, Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Hartmut Weiler

Affiliation Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, United States of America

Charles T. Esmon

Affiliation Oklahoma Medical Research Foundation and Howard Hughes Medical Institute, Oklahoma City, Oklahoma, United States of America

Joanne van Ryn

Affiliation Department of CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany

Erik A. L. Biessen

Affiliation Department of Pathology, Experimental Vascular Pathology Research Group, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

Henri M. H. Spronk

Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

Hugo ten Cate

Affiliation Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

Competing Interests

The authors have the following interests. Boehringer Ingelheim GmbH provided Dabigatran etexilate-supplemented and placebo diets for this study and is the employer of Joanne van Ryn. Dr. ten Cate has received speaker fees from Bayer, Boehringer Ingelheim, GlaxoSmithKline and Leo Pharma. There are no further patents, products in development or marketed products to declare. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JIB EALB SH MJAPD HMS HtC. Performed the experiments: JIB JJTO PL RvO OS STBGL. Analyzed the data: JIB JJTO PL RvO OS STBGL HMS HtC. Contributed reagents/materials/analysis tools: KH TMH MJAPD JLD HW CTE JvR. Wrote the paper: JIB HMS HtC.