About the Authors

Rogerio A. de Almeida

Affiliation Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Anne Fogli

Affiliations Laboratoire GReD (Génétique, Reproduction et Développement), Faculté de Médecine, INSERM U1103 CNRS 6293, Clermont-Ferrand, France, Université de Clermont, UFR Médecine, Clermont-Ferrand, France, Centre Hospitalier Universitaire de Clermont-Ferrand, Service de Biochimie Médicale et Biologie Moléculaire, Clermont-Ferrand, France

Marina Gaillard

Affiliation Laboratoire GReD (Génétique, Reproduction et Développement), Faculté de Médecine, INSERM U1103 CNRS 6293, Clermont-Ferrand, France

Gert C. Scheper

Address Current address: Crucell Holland BV, Leiden, The Netherlands

Affiliation Department of Pediatrics, VU University Medical Centre, Amsterdam, The Netherlands

Odile Boesflug-Tanguy

Affiliations INSERM U676, Hopital Robert Debré, Paris, France, Université Paris Diderot, Sorbonne Cité, UMR U676, Paris, France, APHP, Hopital Robert Debré, Pediatric Neurology and Metabolic Diseases, Reference Center for Leukodystrophies, Paris, France

Graham D. Pavitt

graham.pavitt@manchester.ac.uk

Affiliation Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Competing Interests

Dr. Scheper is an employee Crucell Holland BV. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: GDP GCS OBT. Performed the experiments: RAA AF MG. Analyzed the data: RAA AF GDP. Contributed reagents/materials/analysis tools: GCS OBT GDP. Wrote the paper: GDP AF OBT RAA GCS.