About the Authors

Xu Gu

Xu.Gu@igmm.ed.ac.uk

Affiliation Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

David Reid

Affiliation Gold Standard Simulations Ltd., The Rankine Building, Glasgow, United Kingdom

Desmond J. Higham

Affiliation Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom

David Gilbert

Affiliation School of Information Systems, Computing and Mathematics, Brunel University, Uxbridge, United Kingdom

Competing Interests

The authors have the following interests. David Reid is employed by Gold Standard Simulations Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: XG DR DJH DG. Performed the experiments: XG. Analyzed the data: XG DR. Wrote the paper: XG DR DJH DG.