About the Authors

Samir Attoub

samir.attoub@uaeu.ac.ae

Affiliation Department of Pharmacology & Therapeutics, Faculty of Medicine & Health Sciences, U. A. E. University, Al-Ain, United Arab Emirates

Kholoud Arafat

Affiliation Department of Pharmacology & Therapeutics, Faculty of Medicine & Health Sciences, U. A. E. University, Al-Ain, United Arab Emirates

An Gélaude

Affiliation Laboratory of Experimental Cancer Research, University Hospital, Gent, Belgium

Mahmood Ahmed Al Sultan

Affiliation Department of Pharmacology & Therapeutics, Faculty of Medicine & Health Sciences, U. A. E. University, Al-Ain, United Arab Emirates

Marc Bracke

Affiliation Laboratory of Experimental Cancer Research, University Hospital, Gent, Belgium

Peter Collin

Affiliation Coastside Bio Resources, Stonington, Maine, United States of America

Takashi Takahashi

Affiliation Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan

Thomas E. Adrian

Affiliation Department of Physiology, Faculty of Medicine & Health Sciences, U. A. E. University, Al-Ain, United Arab Emirates

Olivier De Wever

Affiliation Laboratory of Experimental Cancer Research, University Hospital, Gent, Belgium

Competing Interests

Peter Collin is director, laboratory manager, employee and stock-holder of Coastside Bio Resources, a Maine, USA Corporation. Thomas Adrian and Peter Collin are co-inventors of a United States patent describing Frondoside A and other sea cucumber glycosides as putative anti-cancer agents, and may benefit financially if Frondoside A becomes a drug for human cancers. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SA ODW. Performed the experiments: SA KA AG MAAS TEA. Analyzed the data: SA MB TEA ODW. Contributed reagents/materials/analysis tools: PC TT. Wrote the paper: SA ODW TEA MB TT.