About the Authors

Caterina Vacchi-Suzzi

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Florian Hahne

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Philippe Scheubel

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Magali Marcellin

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Valerie Dubost

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Magdalena Westphal

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Catherine Boeglen

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Stine Büchmann-Møller

Affiliation Biomarker Development, Novartis Institute for Biomedical Research, Basel, Switzerland

Ming Sin Cheung

Affiliation Biomarker Development, Novartis Institute for Biomedical Research, Basel, Switzerland

André Cordier

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Christopher De Benedetto

Affiliation Preclinical Safety, Novartis Institute of Biomedical Research, East Hanover, New Jersey, United States of America

Mark Deurinck

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Moritz Frei

Affiliation Biomarker Development, Novartis Institute for Biomedical Research, Basel, Switzerland

Pierre Moulin

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Edward Oakeley

Affiliation Biomarker Development, Novartis Institute for Biomedical Research, Basel, Switzerland

Olivier Grenet

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Armelle Grevot

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Robert Stull

Affiliation Preclinical Safety, Novartis Institute of Biomedical Research, East Hanover, New Jersey, United States of America

Diethilde Theil

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Jonathan G. Moggs

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Estelle Marrer

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Philippe Couttet

philippe.couttet@novartis.com

Affiliation Preclinical Safety, Novartis Institutes of Biomedical Research, Basel, Switzerland

Competing Interests

All authors are employees of the Novartis Pharma AG. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CVS EM PC. Performed the experiments: CVS MM VD MW PS CDB MF CB. Analyzed the data: CVS FH MSC AC. Contributed reagents/materials/analysis tools: SBM EO RS AG. Wrote the paper: CVS PC EM. Supervised the study and experimental design: PC PM AC DT MD OG JGM. Reviewed and commented the manuscript: JGM.