Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA

Karin M. Gilljam; Rebekka Müller; Nina B. Liabakk; Marit Otterlei

doi:10.1371/journal.pone.0049199

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Open Access

Peer-reviewed

Research Article

Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA

Karin M. Gilljam,

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
⨯
Rebekka Müller,

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
⨯
Nina B. Liabakk,

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
⨯
Marit Otterlei

* E-mail: marit.otterlei@ntnu.no

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
⨯

Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA

Karin M. Gilljam,
Rebekka Müller,
Nina B. Liabakk,
Marit Otterlei

Published: November 13, 2012
https://doi.org/10.1371/journal.pone.0049199

About the Authors

Karin M. Gilljam

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Rebekka Müller

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Nina B. Liabakk

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Marit Otterlei

* E-mail: marit.otterlei@ntnu.no

Affiliation Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMG RM MO. Performed the experiments: KMG RM NBL. Analyzed the data: KMG RM NBL MO. Contributed reagents/materials/analysis tools: KMG RM NBL MO. Wrote the paper: KMG RM MO.

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DNA replication
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DNA repair
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Fluorescence resonance energy transfer
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Yellow fluorescent protein
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HeLa cells
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Synthesis phase
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DNA damage
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Cell staining
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