About the Authors

Dennis S. Rice

drice@lexpharma.com

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Gwenn M. Hansen

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Feng Liu

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Mike J. Crist

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Matthew M. Newhouse

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

David Potter

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Nianhua Xu

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Alejandro Abuin

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Peter J. Vogel

Address Current address: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Brian P. Zambrowicz

Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

Competing Interests

Authors are/were employed by Lexicon Pharmaceuticals during the time at which this research was conducted and have received stock options from Lexicon Pharmaceuticals. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DSR GMH DP NX AA BPZ. Performed the experiments: DSR FL MJC MMN NX PV. Analyzed the data: DSR GMH DP AA BPZ. Contributed reagents/materials/analysis tools: BPZ. Wrote the paper: DSR GMH FL MJC MMN DP AA.