About the Authors
- Kelly Coffey
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Affiliation Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Timothy J. Blackburn
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Affiliations Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Research and School of Chemistry, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Susan Cook
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Affiliation Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Bernard T. Golding
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Affiliations Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Research and School of Chemistry, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Roger J. Griffin
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Affiliations Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Research and School of Chemistry, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Ian R. Hardcastle
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Affiliations Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Research and School of Chemistry, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Lorraine Hewitt
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Affiliation Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Kety Huberman
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Affiliation OSI Pharmaceuticals, Inc, Farmingdale, New York, United States of America
- Hesta V. McNeill
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Affiliation Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- David R. Newell
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Affiliation Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Celine Roche
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Affiliations Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Research and School of Chemistry, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Claudia A. Ryan-Munden
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Affiliation Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Anna Watson
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Affiliations Drug Discovery and Imaging Group, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom, Research and School of Chemistry, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
- Craig N. Robson
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* E-mail: c.n.robson@ncl.ac.uk
Affiliation Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Competing Interests
KH was employed by OSI Pharmaceuticals, Inc. Compounds discussed in this article are not patented, in development or being marketed by this company. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: KC IRH RJG BTG CNR. Performed the experiments: LH HVM SC KC TJB BTG RJG IRH KH CR AW DRN CARM. Analyzed the data: KC CNR. Wrote the paper: KC TJB BTG RJG IRH DRN CNR KC.