About the Authors

Ramon Casanova

Casanova@wakehealth.edu

Affiliation Department of Biostatistical Sciences, Wake Forest School of Medicine, North Carolina, United States of America

Fang-Chi Hsu

Affiliation Department of Biostatistical Sciences, Wake Forest School of Medicine, North Carolina, United States of America

Mark A. Espeland, for the Alzheimer's Disease Neuroimaging Initiative

Membership of the Alzheimer's Disease Neuroimaging Initiative is provided in the Acknowledgments.

Competing Interests

ADNI, one of the funders of this study, is partly funded through generous contributions from the following: Abbott; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. .

Author Contributions

Conceived and designed the experiments: RC FCH MAE. Performed the experiments: RC FCH MAE. Analyzed the data: RC FCH MAE. Wrote the paper: RC FCH MAE.