About the Authors

Manuj Tandon

Contributed equally to this work with: Manuj Tandon, Lirong Wang

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Lirong Wang

Contributed equally to this work with: Manuj Tandon, Lirong Wang

Affiliation Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylavania, United States of America

Qi Xu

Affiliation Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylavania, United States of America

Xiangqun Xie

Affiliation Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylavania, United States of America

Peter Wipf

pwipf@pitt.edu (PW); qjw1@pitt.edu (QJW)

Affiliations Department of Chemistry and Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylavania, United States of America

Qiming Jane Wang

pwipf@pitt.edu (PW); qjw1@pitt.edu (QJW)

Affiliation Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

Hoffmann-La Roche, Inc. has provided the authors as a generous gift the screening samples, the kinase profile and the kinome dendrogram data in this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: QJW PW XX. Performed the experiments: MT LW QX. Analyzed the data: MT LW QX XX PW QJW. Contributed reagents/materials/analysis tools: QJW PW XX. Wrote the paper: QJW PW XX MT LW.