About the Authors
Division of Cardiology, Duke University Medical Center/Duke Clinical Research Institute, Durham, North Carolina, United States of America
Division of Cardiology, Department of Veterans Affairs, Washington, District of Columbia, United States of America
Division of Cardiology, Department of Veterans Affairs, Minneapolis, Minnesota, United States of America
National Heart, Lung, and Blood Institute, National Institutes of Health, Washington, District of Columbia, United States of America
Department of Medicine, University of Maryland, Baltimore, Maryland, United States of America
Heart and Vascular Institute, Advocate Christ Medical Center, Oak Lawn, Illinois, United States of America
Division of Cardiology/Cardiovascular Institute, University of Colorado School of Medicine, Aurora, Colorado, United States of America
Division of Cardiology, University of Florida Health Sciences Center, Jacksonville, Florida, United States of America
Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
ARCA biopharma, Broomfield, Colorado, United States of America
Department of Psychiatry and Behavioral United States of America, Sciences and of Pediatrics, Stanford University, Stanford, California, United States of America
Ohio State University, Columbus, Ohio, United States of America
Center for Personalized Medicine and Genomics, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
Drs Bristow, Carr, Murphy, and Port and Mr Davis are employees of and own stock or stock options in ARCA biopharma, Inc., which owns the rights to bucindolol. Drs Fiuzat, Liggett, Lindenfeld, and Robertson are consultants of ARCA biopharma. Also, Drs Fiuzat and Liggett own stock or stock options in ARCA biopharma. Drs O'Connor, Carson, Anand, Plehn, Gottlieb, Silver, Miller, White, Lazzeroni, and Abraham and Mr Walsh, Ms Nelson, and Mr Medway have no conflicts to report. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: GD ADR JDP WTA SBL MRB. Performed the experiments: MF RW PN AM SBL. Analyzed the data: CMO PEC ISA JFP SSG MAS JL ABM MW GD ADR LCL MRB. Wrote the paper: MF GAM SBL MRB. Interpreted the data: CMO MF PEC ISA JFP SSG MAS JL ABM MW RW PN AM GD ADR JDP JC GAM LCL WTA SBL MRB. Revised the paper for important intellectual content: CMO MF PEC ISA JFP SSG MAS JL ABM MW GD ADR JDP JC GAM LCL SBL MRB. Contributed reagents/materials/analysis tools, procurement of human hearts: AM.