Ubiquitin-Associated (UBA) Domain in Human Fas Associated Factor 1 Inhibits Tumor Formation by Promoting Hsp70 Degradation

Jae-Jin Lee; Young Mee Kim; Jaeho Jeong; Duk Soo Bae; Kong-Joo Lee

doi:10.1371/journal.pone.0040361

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Open Access

Peer-reviewed

Research Article

Ubiquitin-Associated (UBA) Domain in Human Fas Associated Factor 1 Inhibits Tumor Formation by Promoting Hsp70 Degradation

Jae-Jin Lee,

Affiliation Division of Life and Pharmaceutical Sciences, Department of Bioinspired Science, Drug Discovery Research, College of Pharmacy, Center for Cell Signaling, Ewha Womans University, Seoul, Korea
⨯
Young Mee Kim,

Affiliation Division of Life and Pharmaceutical Sciences, Department of Bioinspired Science, Drug Discovery Research, College of Pharmacy, Center for Cell Signaling, Ewha Womans University, Seoul, Korea
⨯
Jaeho Jeong,

Affiliation Division of Life and Pharmaceutical Sciences, Department of Bioinspired Science, Drug Discovery Research, College of Pharmacy, Center for Cell Signaling, Ewha Womans University, Seoul, Korea
⨯
Duk Soo Bae,

Affiliation Department of Obstetrics and Gynecology, Samsung Medical Center, SungKyunKwan University, Seoul, Korea
⨯
Kong-Joo Lee

* E-mail: kjl@ewha.ac.kr

Affiliation Division of Life and Pharmaceutical Sciences, Department of Bioinspired Science, Drug Discovery Research, College of Pharmacy, Center for Cell Signaling, Ewha Womans University, Seoul, Korea
⨯

Ubiquitin-Associated (UBA) Domain in Human Fas Associated Factor 1 Inhibits Tumor Formation by Promoting Hsp70 Degradation

Jae-Jin Lee,
Young Mee Kim,
Jaeho Jeong,
Duk Soo Bae,
Kong-Joo Lee

Published: August 2, 2012
https://doi.org/10.1371/journal.pone.0040361

About the Authors

Jae-Jin Lee

Affiliation Division of Life and Pharmaceutical Sciences, Department of Bioinspired Science, Drug Discovery Research, College of Pharmacy, Center for Cell Signaling, Ewha Womans University, Seoul, Korea

Young Mee Kim

Jaeho Jeong

Duk Soo Bae

Affiliation Department of Obstetrics and Gynecology, Samsung Medical Center, SungKyunKwan University, Seoul, Korea

Kong-Joo Lee

* E-mail: kjl@ewha.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: J-JL YMK K-JL. Performed the experiments: J-JL YMK JJ. Analyzed the data: J-JL JJ DSB K-JL. Contributed reagents/materials/analysis tools: J-JL YMK DSB. Wrote the paper: J-JL K-JL.

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Protein domains
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Immunoprecipitation
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Cervical cancer
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Transfection
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Apoptosis
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Gastric cancer
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HeLa cells
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Hyperexpression techniques
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