About the Authors

Robert E. Featherstone

Affiliation Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Jennifer M. Phillips

Affiliation Department of Psychology, Mount St. Mary’s University, Emmitsburg, Maryland, United States of America

Tony Thieu

Affiliation Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Richard S. Ehrlichman

Affiliation Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Tobias B. Halene

Affiliation Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Steven C. Leiser

Affiliation AstraZeneca, Wilmington, Delaware, United States of America

Edward Christian

Affiliation AstraZeneca, Wilmington, Delaware, United States of America

Edwin Johnson

Affiliation AstraZeneca, Wilmington, Delaware, United States of America

Caryn Lerman

Affiliation Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Steven J. Siegel

siegels@upenn.edu

Affiliation Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have the following interests. Steven Leiser, Edward Christian and Edwin Johnson are former employees of AstraZeneca who provided a pilot grant for this study. Steven Siegel has been a consultant and/or has received grant support from the following companies that develop and/or market medications: NuPathe, AstraZeneca, and Merck, all unrelated to the current manuscript. Caryn Lerman has been a consultant and/or has received grant support from the following companies that develop and/or market smoking cessation medications: AstraZeneca, Glaxo SmithKline, Novartis and Pfizer, all unrelated to the current manuscript. AstraZeneca supplied AZD3480 for use in this study. There are no other patents, products in development or other marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RF JP RE TH SL EC EJ JS. Analyzed the data: RF JP TT TH EJ EC JS. Wrote the paper: RF JP TT JS. Obtained funding for the experiments: SS CL.