About the Authors

Dongsha Wang

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada

Moshe Szyf

linda.booij@umontreal.ca (LB); moshe.szyf@mcgill.ca (MS); tremblar@grip.umontreal.ca (RET)

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada

Chawki Benkelfat

Affiliation Department of Psychiatry, McGill University, Montreal, Quebec, Canada

Nadine Provençal

Affiliations Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Quebec, Canada

Gustavo Turecki

Affiliation Department of Psychiatry, McGill University, Montreal, Quebec, Canada

Doretta Caramaschi

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

Sylvana M. Côté

Affiliation Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada

Frank Vitaro

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Psycho-Education, University of Montreal, Montreal, Quebec, Canada

Richard E. Tremblay

linda.booij@umontreal.ca (LB); moshe.szyf@mcgill.ca (MS); tremblar@grip.umontreal.ca (RET)

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Psychology and Pediatrics, University of Montreal, Montreal, Quebec, Canada, School of Public Health, Psychotherapy and Population Sciences, University College Dublin, Dublin, Ireland

Linda Booij

linda.booij@umontreal.ca (LB); moshe.szyf@mcgill.ca (MS); tremblar@grip.umontreal.ca (RET)

Affiliations Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada, Department of Psychiatry, McGill University, Montreal, Quebec, Canada, Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada

Competing Interests

The authors have the following interests to declare. This study was supported by a GlaxoSmithKline-Canadian Institues of Health Research professorship in pharmacology. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS LB RET. Performed the experiments: DW. Analyzed the data: DW LB. Contributed reagents/materials/analysis tools: NP. Wrote the paper: DW LB MS. Blood RNA extraction: DC. Genotyping of serotonin transporter: GT. Collection and analysis of PET data: LB RET CB. Design of the longitudinal cohort study: SC FV RET.