About the Authors

Brante P. Sampey

Current address: Metabolon, Inc., Durham, North Carolina, United States of America

Affiliation Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Alex J. Freemerman

Affiliation Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Jimmy Zhang

Affiliation Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Pei-Fen Kuan

Affiliations Department of Biostatistics, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Joseph A. Galanko

Affiliation Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Thomas M. O'Connell

Affiliation LipoScience Inc., Raleigh, North Carolina, United States of America

Olga R. Ilkayeva

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

Michael J. Muehlbauer

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

Robert D. Stevens

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America

Christopher B. Newgard

Affiliations Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America

Heather A. Brauer

Affiliation Department of Epidemiology, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Melissa A. Troester

Affiliations Department of Epidemiology, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Liza Makowski

liza.makowski@unc.edu

Affiliations Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Competing Interests

The authors declare the following interests: The project was partially funded by A Freedom to Discover Award from Bristol Meyers Squibb (http://www.bms.com/foundation/what_we_support/Pages/ftd_grants_awards.aspx) to C.B.N. B.P.S. and T.M.O. were employed at UNC while analysis of this manuscript was completed, and currently are employed by Metabolon, Inc. and Liposcience, Inc., respectively. There are no declarations relating to employment, consultancy, patents or products in development or marketed products, etc. with regard to this work. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LM BPS CBN. Performed the experiments: LM BPS AJF JZ. Analyzed the data: PFK TMO JAG HAB MAT LM. Contributed reagents/materials/analysis tools: LM CBN MAT. Wrote the paper: LM BPS CBN. Metabolomics core: ORI MJM RDS.