About the Authors

Yang Yu

Contributed equally to this work with: Yang Yu, Lan Zhang

Current address: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Lan Zhang

Contributed equally to this work with: Yang Yu, Lan Zhang

Current address: Department of Pharmacology, Xuanwu Hospital, the Capital Medical University, Beijing, China

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Xiaojing Li

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Xiaoqin Run

Current address: Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Zhihou Liang

Current address: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Yi Li

Current address: Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Ying Liu

Current address: Department of Internal Medicine, The Mount Vernon Hospital, Mount Vernon, New York, United States of America

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Moon H. Lee

Affiliation Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Inge Grundke-Iqbal

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Khalid Iqbal

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

David J. Vocadlo

Affiliation Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada

Fei Liu

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Cheng-Xin Gong

chengxin.gong@csi.cuny.edu

Affiliation Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America

Competing Interests

Co-author Cheng-Xin Gong is a PLoS ONE Editorial Board member. David J. Vocadlo is a consultant, shareholder, and member of the Scientific Advisory Board and Cheng-Xin Gong is a member of the Scientific Advisory Board of Alectos Therapeutics, Inc., Burnaby, Canada. These do not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YY LZ IGI KI FL CXG. Performed the experiments: LZ XL XR ZL Y. Li Y. Liu. Analyzed the data: YY LZ XL XR ZL Y. Li Y. Liu MHL IGI KI DJV FL CXG. Contributed reagents/materials/analysis tools: MHL IGI KI DJV FL CXG. Wrote the paper: YY XL CXG.