About the Authors

Katharina Böckl

Contributed equally to this work with: Katharina Böckl, Jens Wild

Affiliation Institute of Medical Microbiology, University of Regensburg, Regensburg, Germany

Jens Wild

Contributed equally to this work with: Katharina Böckl, Jens Wild

Affiliation Institute of Medical Microbiology, University of Regensburg, Regensburg, Germany

Simon Bredl

Current address: Redbiotec AG, Schlieren, Switzerland

Affiliation Institute of Medical Microbiology, University of Regensburg, Regensburg, Germany

Kathrin Kindsmüller

Current address: Emergent BioSolutions, Munich, Germany

Affiliation Institute of Medical Microbiology, University of Regensburg, Regensburg, Germany

Josef Köstler

Affiliation Institute of Medical Microbiology, University of Regensburg, Regensburg, Germany

Ralf Wagner

ralf.wagner@klinik.uni-regensburg.de

Affiliations Institute of Medical Microbiology, University of Regensburg, Regensburg, Germany, Geneart AG/Life Technologies, Regensburg, Germany

Competing Interests

The authors declare that no competing interests exist. Simon Bredl and Kathrin Kindsmüller are former members of the group of Ralf Wagner and left the Institute after completing the experiments presented in this manuscript. The company addresses represent their present working addresses. Ralf Wagner is founder and CEO/CSO of GeneArt. He is also Vice President at Life Technologies and as such representing the Synthetic Biology Business Unit within Life technologies. Ralf Wagner is employee of Life Technologies as well as the University of Regensburg. GeneArt and Life Technologies hold IP on the some RNA and codon optimized HIV CN54 genes, which were analyzed in this study. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KB JW SB KK JK RW. Performed the experiments: KB JW SB. Analyzed the data: KB JW SB. Wrote the paper: KB JW RW.